Before the SARS-CoV-2 pandemic took hold, few people were aware of the existence of mRNA vaccines. Yet after months of vaccinations from Moderna and BioNTech and clear indications of robust protection to millions of people, it now seems hard to imagine a world without mRNA vaccine technology, especially as more traditional vaccines seem to falter against the new COVID-19 variants and the ravages of so-called ?Long COVID? become more apparent.